| |
Non adjusted HR (95% CI) P-value |
Adjusted for tumor thickness/in situ HR (95% CI) P-value |
| Age group |
|
|
|
|
|
|
| 20-49 |
1.0 |
ref. |
|
1.0 |
ref. |
|
| 50-64 |
1.5 |
(0.61-3.5) |
0.39 |
1.1 |
(0.45-2.8) |
0.82 |
| 65-74 |
1.1 |
(0.43-3.1) |
0.78 |
0.6 |
(0.19-1.6) |
0.26 |
| 75+ |
1.6 |
(0.65-4.1) |
0.29 |
0.9 |
(0.36-2.4) |
0.89 |
| Sex |
|
|
|
|
|
|
| Male |
1.0 |
ref. |
|
1.0 |
ref. |
|
| Female |
0.76 |
(0.42-1.4) |
0.35 |
0.89 |
(0.49-1.6) |
0.7 |
| Year of diagnosis |
|
|
|
|
|
|
| 1996-1999 |
1.0 |
ref. |
|
1.0 |
ref. |
|
| 2000-2003 |
0.82 |
(0.46-1.5) |
0.52 |
1.12 |
(0.61-2.1) |
0.71 |
| Tumor thickness1 |
|
|
|
|
|
|
| 0-0.99 mm |
1.41 |
(0.38-5.2) |
0.61 |
- |
- |
0.61 |
| 1-1.99 mm |
ref. |
|
|
- |
- |
|
| 2-2.99 mm |
3.56 |
(1.0-12) |
0.04 |
- |
- |
0.04 |
| 3-3.99 mm |
5.05 |
(1.4–18) |
0.01 |
- |
- |
0.01 |
| 4+ mm |
8.43 |
(2.9-25) |
<0.001 |
- |
- |
<0.001 |
| Missing data |
0.89 |
(0.22-3.6) |
0.87 |
- |
- |
0.87 |
| Clark level |
|
|
|
|
|
|
| I-II |
0.12 |
(0.03-0.51) |
0.004 |
Excluded2 |
NA |
|
| III |
1.0 |
ref. |
|
1.0 |
ref. |
|
| IV |
1.7 |
(0.84-3.3) |
0.14 |
1.19 |
(0.56-2.6) |
0.65 |
| V |
4.1 |
(1.6-10) |
0.003 |
1.71 |
(0.61-4.8) |
0.31 |
| Missing data |
3.0 |
(0.67-13) |
0.15 |
Excluded2 |
NA |
|
| Ulceration |
|
|
|
|
|
|
| No ulceration |
1.0 |
ref. |
|
1.0 |
ref. |
|
| Ulceration |
5.8 |
(3.0-11) |
<0.001 |
3.9 |
(1.9-7.9) |
<0.001 |
| Missing data |
0.73 |
(0.24-2.2) |
0.57 |
0.94 |
(0.23-3.9) |
0.93 |
| Histopathology |
|
|
|
|
|
|
| NM |
ref. |
|
|
- |
- |
|
| SSM |
0.45 |
(0.24-0.85) |
0.01 |
0.76 |
(0.38-1.5) |
0.43 |
| In situ |
0.05 |
(0.01-0.35) |
0.003 |
Excluded3 |
NA |
|
| Others |
0.10 |
(0.01-0.78) |
0.03 |
0.12 |
(0.02-0.93) |
0.04 |
| Missing data |
0.38 |
(0.13-1.1) |
0.07 |
0.41 |
(0.10-1.7) |
0.22 |
| Node status |
|
|
|
|
|
|
| N0 |
ref. |
|
|
ref. |
|
|
| N+ |
12.03 |
(6.3-23) |
<0.001 |
6.48 |
(3.3-13) |
<0.001 |
| NX |
Excluded4 |
NA |
|
Excluded4 |
NA |
|
| Fraction (%) |
|
|
|
|
|
|
| 0 (0) |
0.34 |
(0.04-2.6) |
0.3 |
0.27 |
(0.03-2.2) |
0.22 |
| 1-25 (1) |
ref. |
|
|
ref. |
|
|
| 25-75 (2) |
0.89 |
(0.37-2.2) |
0.81 |
0.67 |
(0.27-1.7) |
0.39 |
| 75-100 (3) |
0.39 |
(0.18-0.85) |
0.02 |
0.44 |
(0.20-1.0) |
0.05 |
| Missing data |
Excluded4 |
NA |
|
Excluded4 |
NA |
|
| Intensity of staining |
|
|
|
|
|
|
| Negative (0) |
0.30 |
(0.04-2.5) |
0.26 |
0.31 |
(0.04-2.55) |
0.27 |
| Weak (1) |
1.0 |
ref. |
|
1.0 |
ref. |
|
| Strong (2) |
0.44 |
(0.20-0.98) |
0.05 |
0.59 |
(0.26-1.36) |
0.22 |
| Missing data |
Excluded4 |
NA |
|
Excluded4 |
NA |
|
| MITF Fraction/Intensity |
|
|
|
|
|
|
| 3/2 |
1.0 |
ref. |
|
1.0 |
ref. |
|
| 2/2 |
1.9 |
(0.79-4.3) |
0.16 |
1.2 |
(0.5-3.1) |
0.64 |
| 3/1 |
2.1 |
(0.49-8.9) |
0.31 |
1.5 |
(0.35-6.7) |
0.58 |
| 2/1 |
4.9 |
(1.7-14) |
0.004 |
2.9 |
(0.94-8.7) |
0.06 |
| 1/2 |
2.9 |
(1.3-6.4) |
0.01 |
2.5 |
(1.1-6.1) |
0.04 |
| 1/1 |
1.7 |
(0.23-13) |
0.61 |
1.6 |
(0.21-12) |
0.65 |
| 0/0 |
0.89 |
(0.12-6.6) |
0.91 |
0.62 |
(0.08-4.7) |
0.65 |
| Missing data |
Excluded4 |
NA |
|
Excluded4 |
NA |
|
1Applies to invasive tumors
2Excluded due to no events in the categories Clark level I-II and missing Clark
level for any non-missing level of tumor thickness/in situ
3Excluded since the in situ tumors are nested within the variable tumor thickness/
in situ.
4Excluded due to no events in the category
NA: Not applicable, NM: Nodular malignant melanoma, ref: Reference, SSM:
Superficial spreading melanoma |
