Non adjusted HR (95% CI) P-value Adjusted for tumor thickness/in situ HR (95% CI) P-value
Age group            
20-49 1.0 ref.   1.0 ref.  
50-64 1.5 (0.61-3.5) 0.39 1.1 (0.45-2.8) 0.82
65-74 1.1 (0.43-3.1) 0.78 0.6 (0.19-1.6) 0.26
75+ 1.6 (0.65-4.1) 0.29 0.9 (0.36-2.4) 0.89
Sex            
Male 1.0 ref.   1.0 ref.  
Female 0.76 (0.42-1.4) 0.35 0.89 (0.49-1.6) 0.7
Year of diagnosis            
1996-1999 1.0 ref.   1.0 ref.  
2000-2003 0.82 (0.46-1.5) 0.52 1.12 (0.61-2.1) 0.71
Tumor thickness1            
0-0.99 mm 1.41 (0.38-5.2) 0.61 - - 0.61
1-1.99 mm ref.     - -  
2-2.99 mm 3.56 (1.0-12) 0.04 - - 0.04
3-3.99 mm 5.05 (1.4–18) 0.01 - - 0.01
4+ mm 8.43 (2.9-25) <0.001 - - <0.001
Missing data 0.89 (0.22-3.6) 0.87 - - 0.87
Clark level            
I-II 0.12 (0.03-0.51) 0.004 Excluded2 NA  
III 1.0 ref.   1.0 ref.  
IV 1.7 (0.84-3.3) 0.14 1.19 (0.56-2.6) 0.65
V 4.1 (1.6-10) 0.003 1.71 (0.61-4.8) 0.31
Missing data 3.0 (0.67-13) 0.15 Excluded2 NA  
Ulceration            
No ulceration 1.0 ref.   1.0 ref.  
Ulceration 5.8 (3.0-11) <0.001 3.9 (1.9-7.9) <0.001
Missing data 0.73 (0.24-2.2) 0.57 0.94 (0.23-3.9) 0.93
Histopathology            
NM ref.     - -  
SSM 0.45 (0.24-0.85) 0.01 0.76 (0.38-1.5) 0.43
In situ 0.05 (0.01-0.35) 0.003 Excluded3 NA  
Others 0.10 (0.01-0.78) 0.03 0.12 (0.02-0.93) 0.04
Missing data 0.38 (0.13-1.1) 0.07 0.41 (0.10-1.7) 0.22
Node status            
N0 ref.     ref.    
N+ 12.03 (6.3-23) <0.001 6.48 (3.3-13) <0.001
NX Excluded4 NA   Excluded4 NA  
Fraction (%)            
0 (0) 0.34 (0.04-2.6) 0.3 0.27 (0.03-2.2) 0.22
1-25 (1) ref.     ref.    
25-75 (2) 0.89 (0.37-2.2) 0.81 0.67 (0.27-1.7) 0.39
75-100 (3) 0.39 (0.18-0.85) 0.02 0.44 (0.20-1.0) 0.05
Missing data Excluded4 NA   Excluded4 NA  
Intensity of staining            
Negative (0) 0.30 (0.04-2.5) 0.26 0.31 (0.04-2.55) 0.27
Weak (1) 1.0 ref.   1.0 ref.  
Strong (2) 0.44 (0.20-0.98) 0.05 0.59 (0.26-1.36) 0.22
Missing data Excluded4 NA   Excluded4 NA  
MITF Fraction/Intensity            
3/2 1.0 ref.   1.0 ref.  
2/2 1.9 (0.79-4.3) 0.16 1.2 (0.5-3.1) 0.64
3/1 2.1 (0.49-8.9) 0.31 1.5 (0.35-6.7) 0.58
2/1 4.9 (1.7-14) 0.004 2.9 (0.94-8.7) 0.06
1/2 2.9 (1.3-6.4) 0.01 2.5 (1.1-6.1) 0.04
1/1 1.7 (0.23-13) 0.61 1.6 (0.21-12) 0.65
0/0 0.89 (0.12-6.6) 0.91 0.62 (0.08-4.7) 0.65
Missing data Excluded4 NA   Excluded4 NA  
1Applies to invasive tumors
2Excluded due to no events in the categories Clark level I-II and missing Clark
level for any non-missing level of tumor thickness/in situ
3Excluded since the in situ tumors are nested within the variable tumor thickness/ in situ.
4Excluded due to no events in the category
NA: Not applicable, NM: Nodular malignant melanoma, ref: Reference, SSM:
Superficial spreading melanoma
Table 2: Hazard ratios (HR) with 95% confidence intervals (CI) for death in malignant melanoma estimated in Cox Proportional Hazards models. One model adjusted for tumor thickness/in situ.