The Study Group VEGF BK AII AFFINITY CONSTANTS RANGING BETWEEN, M IgM IgG IgM IgG IgM IgG Healthy Individuals 10-6-10-7 10-5-10-8 10-6-10-7 10-5-10-8 10-6-10-8 10-5-10-7 Patients with osteoarthritis of the knee 10-10- 10-11 10-4-10-6 10-9- 10-11 10-3-10-5 10-9- 10-10 10-4-10-5

Table 4: The affinity of natural antibodies against endogenous mediators from both osteoarthritis of the knee and normal sera.