Structurally % Significant Inhibition Similar Inhibitors % Significant Inhibition BK-IgG BK-IgM AII-IgG AII-IgM Angiotensin II 0.12 0.01 100 100 Bradykinin 100 100 0.02 0.01 Vasopressin 0.003 0.01 0.07 0.001 Dermorphin 0.001 0.001 0.003 0.001 Beta-Endorphin 0.007 0.001 0.001 0.02

Table 5: The cross-reactivity of affinity-purified natural antibodies against endogenous mediators from osteoarthritis of the knee and normal sera.