Figure 5: ANXA1 expression of breast cancer of different histological grades; A, B, C. Expression of ANXA1 is absent in Grade I, Grade II and some of Grade III breast cancer cells. Stromal cells are faintly positive for ANXA1. D-G. 29.6% of Grade III breast cancers have an altered pattern of ANXA1 expression along with varied subcellular localization. ANXA1 staining could be found in the cytoplasm (D), in the nuclei with only very faint cytoplasmic staining (E), in both cytoplasm and nuclei (F), or in the membrane (G) of breast cancer cells.