Figure 3: Individual plots of disease stages and serum HB-EGF concentrations determined by immuno-PCR method.The lower limit of quantification was 5 pg/mL, and serum HB-EGF concentrations below the limit of quantification were regarded as 5 pg/mL. Open circles represent the individual HB-EGF concentrations (n=69)a). Bars indicate mean. This plot shows a tendency that higher serum HB-EGF concentrations are observed in higher stages. a) One out of 70 patients had no information regarding disease stage.