TRACP 5b [U/l] AP [U/l] N Mean Std. Dev. Range Mean Std.Dev. Range Patients without malignant disease 19 4.22 2.37 1.87-10 171.37 114.11 59-428 Patients with known malignant disease without bone metastasis 60 5.04 2.12 1.71-10 262.80 219.47 69-1045 Patients with known bone metastasis 17 6.75 3.0 2.23-10 495.41 712.51 105-3053

Table 1: Activity of TRACP 5b and AP [U/l] in our different study groups.