Variables Hazard ratio (95% CI) P value
WBC (×103/μl)* 1.327 (1.170-1.506) <0.001
CRC stage (I + II + III vs. IV) 8.788 (3.928-19.662) <0.001
Lower level of lipocalin 2 [< 116.7 (ng/ml)] 6.854 (2.928-16.047) <0.001
CEA (×10 ng/ml)*† 1.004 (1.0005-1.0083) 0.028
*Value was used as continuity.
†Indicated increased each 1.001 Hazard ratio with respect to increase in 10 ng/ml of CEA.
‡Primary combined endpoint was defined as any cause of death or occurrence of new onset of metastasis during long-term follow-up.
CI: Confidence Interval; CEA: Carcinoembryonic Antigen; CRC: Colorectal
Cancer.
Table 4: Multivariable Stepwise Cox Regression Analysis of Predictors for Primary
Combined Endpoint During Long-term Follow-up‡.