Figure 2: Urinary parameter (urine volume, uVol; urinary creatinine, uCr; urine creatinine clearance, uCrCl; urinary total protein, uTP [normalized to concurrent urinary creatinine concentrations, uCr]) changes in male Sprague-Dawley rats administered Vehicle (Veh, 0.9% saline) or Doxorubicin (Dox, 5 mg/kg/dose) and samples collected on study days 7 and 14. Values significantly different from vehiclecontrol are indicated as ***p<0.001 or *p<0.05.