Figure 4: Changes in novel urinary biomarkers (urinary albumin, uAlb; urinary lipocalin-2, uLpn2; urinary kidney injury molecule 1, KIM-1; urinary osteopontin, uOpn) in male Sprague-Dawley rats administered Vehicle (Veh, 0.9% saline) or Doxorubicin (Dox, 5 mg/kg/dose) and samples collected on study days 7 and 14. Urinary biomarkers were normalized to concurrent urinary creatinine (uCr) concentrations. §Doxorubicin-induced increased uAlb concentrations were above the upper limit of assay detection. Values significantly different from vehicle control are indicated as ***p<0.001, **p<0.01 or *p<0.05.