Experimental group Animal #
Control:
Vehicle (0.9% Saline)

1-5
Nephrotoxicant test article:

Doxorubicin (5 mg/kg/dose)
21-25
Doxorubicin (7.5 mg/kg/dose) 31-35
Doxorubicin (10 mg/kg/dose) 41-45
On study days 1 and 8, male Sprague-Dawley rats were administered via a lateral tail vein a bolus intravenous injection of either Vehicle (0.9% Saline) or Doxorubicin. Study termination was on day 14.
Table 1: Experimental group assignments.