| |
Study Day 7 |
| |
Animal# |
BUN(mg/dL) |
sCr(mg/dL) |
sChol(mg/dL) |
sTrig(mg/dL) |
| Vehicle(0.9% Saline) |
1 |
7 |
0.4 |
98 |
88 |
| 2 |
10 |
0.4 |
74 |
104 |
| 3 |
12 |
0.5 |
89 |
76 |
| 4 |
12 |
0.4 |
74 |
52 |
| 5 |
11 |
0.5 |
84 |
106 |
 |
10.4 ± 0.9 |
0.4 ± 0.0 |
83.8 ± 4.6 |
85.2 ± 10.0 |
| Doxorubicin(5 mg/kg/dose) |
21 |
9 |
0.4 |
119 |
70 |
| 22 |
12 |
0.4 |
101 |
87 |
| 23 |
11 |
0.3 |
78 |
59 |
| 24 |
12 |
0.5 |
129 |
58 |
| 25 |
12 |
0.5 |
117 |
70 |
|
11.2 ± 0.6 |
0.4 ± 0.0 |
108.8 ± 8.9* |
68.8 ± 5.2 |
| Fold Δ |
1.1 |
1.0 |
1.3 |
0.8 |
| |
Study Day 14 |
| Vehicle(0.9% Saline) |
1 |
9 |
0.4 |
84 |
49 |
| 2 |
12 |
0.4 |
70 |
83 |
| 3 |
12 |
0.4 |
74 |
68 |
| 4 |
16 |
0.5 |
84 |
44 |
| 5 |
13 |
0.4 |
78 |
74 |
|
12.4 ± 1.1 |
0.4 ± 0.0 |
78.0 ± 2.8 |
63.6 ± 7.4 |
| Doxorubicin (5 mg/kg/dose) |
21 |
26 |
0.5 |
363 |
247 |
| 22 |
28 |
0.3 |
341 |
365 |
| 23 |
16 |
0.3 |
141 |
94 |
| 24 |
26 |
0.4 |
506 |
504 |
| 25 |
33 |
0.4 |
428 |
515 |
|
25.8 ± 2.8** |
0.4 ± 0.0 |
355.8 ± 60.9** |
345.0 ± 79.8** |
| Fold Δ |
2.1 |
1.0 |
4.6 |
5.4 |
| Values significantly different from Vehicle (0.9% Saline) control are indicated as**p<0.01 or *p<0.05. |
|
