Study Day 7
  Animal# uVol(mL) uCr(mg/dL) uCrCl(mL/min/Kg) uTP/uCr(mg/mg)
Vehicle(0.9% Saline) 1 21.20 29.7 5.2 0.3
2 32.40 20.7 5.5 0.6
3 15.30 44.7 4.1 0.6
4 17.12 31.9 4.1 0.5
5 18.19 40.5 4.4 0.5
20.8 ± 3.0 33.5 ± 4.2 4.7 ± 0.3 0.5 ± 0.1
Doxorubicin(5 mg/kg/dose) 21 12.46 50.1 5.7 0.7
22 12.48 31.3 3.4 0.8
23 14.14 68.2 11.4 0.4
24 11.95 82.6 6.5 1.4
25 16.02 66.4 7.0 2.8
13.4 ± 0.7* 59.7 ± 8.8* 6.8 ± 1.3 1.2 ± 0.4
Fold Δ 0.6 1.7 1.4 3.4
  Study Day 14
Vehicle (0.9% Saline) 1 17.37 47.8 6.3 0.8
2 28.38 46.5 10.2 0.9
3 11.38 43.0 3.5 0.6
4 9.34 47.1 2.7 0.7
5 13.45 40.0 3.8 0.5
  16.0 ± 3.4 44.9 ± 1.5 5.3 ± 1.4 0.7 ± 0.1
Doxorubicin(5 mg/kg/dose) 21 2.51 145.5 6.4 55.9
22 11.47 51.5 3.9 55.8
23 5.19 102.0 12.7 31.0
24 4.16 107.3 6.7 59.5
25 6.22 63.2 7.8 57.8
5.9 ± 1.5* 93.9 ± 16.8* 5.0 ± 1.0 52.0 ± 5.3***
Fold Δ 0.4 2.1 0.9 74.3
Values significantly different from Vehicle (0.9% Saline) control are indicated as***p<0.001 or *p<0.05. Urinary total protein (uTP) was normalized to concurrent urinary creatinine concentrations (uCr).
Table 3: Urinary parameter changes on days 7 and 14.