Progressive sarcoidosis n=18 Non active sarcoidosis n=25 Sarcoidosis Stage I n=11 Sarcoidosis Stage II n=20  Sarcoidosis Stage III n=12
Age (years)
(mean ± SEM)
Median (Interquartile range)
35.1 ±1.9
32.5 (30.0 – 40.0)
36.2 ± 1.7
34.0 (29.0 – 40.0)
30.3 ± 1.5
29.0 (29.0 – 30.8)       
35.7 ± 1.9
33.5 (30.5 – 39.0)       
40.3 ± 2.3
40.0 (33.5 – 44.3)                    
FEV1 (% of predicted)
(mean  SEM)
Median (Interquartile range)
87.1 ± 2.0
84.0 (81.0 – 92.0)
85.4 ± 2.4
87.0 (80.0 – 94.0)
87.7 ± 2.7       
90.0 (82.8 – 101.0)                  
87.2 ± 1.8
85.0 (80.5 – 97.3)
83.1 ± 4.3
85.0 (81.0 – 91.5)
FVC  (% of predicted)
(mean ±   SEM
Median (Interquartile range)
96.8 ± 3.4
95.0 (88.0 – 108.0)
95.9 ±2.7
98.0     (91.0 – 103.0)
100.2 ± 3.7     
100.0 ( 96.0 – 105.5)  
97.6 ± 2.8
100.0 (89.5 – 104.0)
90.7 ± 4.6
90.0 (82.8 – 101.0)     
FEV1%VC (%)
(mean ±SEM)
Median (Interquartile range)
75.6 ± 1.8
74.5 (70.0 - 82.0)
75.7 ± 1.2
75.5 (71.0 – 79.0)
77.0 ± 1.8
77.0 (74.0 – 80.0)                    
74.8 ± 1.5
74.0 (70.5 – 77.5)
75.8 ± 2.2
75.0 (68.8 – 83.5)
HGF pg/ml
Mean± SEM
Median (Interquartile range)
1260.7 ± 83.7
1204.0 (1054.0 – 1436.0) ***
802.7 ± 34.8
744.5 (677.0 – 935.0)
1105.4 ± 101.8           
974.0 (914.0 – 1215.5)
947.5 ± 67.0
909.0 (694.5 – 1132.0)
958.0 ± 116.6
754.0 (690.5 – 1227.5)
*** p<0.001 progressive vs stable, non-active sarcoidosis
Table 2: Spirometric parameters and Hepatocyte Growth Factor (HGF) concentrations in progressive or non-active sarcoidosis assigned to clinical stages.