Genotypea Controls (n)  (n=152)% BC (n) (n=144)% ORb 95%CIc pd
PONI Q192R QQ 143 94.1 110 76.4 1.0   1
QR 7 4.6 30 20.8 5.6 2.23-14.51 0.000
RR 2 1.3 4 2.8 2.6 0.40-20.83 0.259
Q 0.096   0.87        
R 0.04   0.13        
PONI L55M LL 130 85.5 70 48.6 1.0   1
LM 7 4.6 58 40.3 15.4 6.34-39.09 0.000
MM 15
9.9 16 11.1 2.0 0.87-4.53 0.076
L 0.88   0.69        
M 0.12   0.31        
GLOI AA 55 36.2 0 0 undefinited   1
AE 20 13.1 56 38.9 undefinited 28.911-inf 0.000
EE 77 50.6 88 61.1 undefinited 12.535-inf <0.001
A 0.43   0.2        
E 0.57   0.8        
a Genotypes with Q/R, L/M and A/E alleles, respectively
bOR, odds ratios are calculated relative to subjects with the Q/Q, L/L and A/A genotypes, respectively
c CI, confidence interval
dTwo-sided χ2 test; p< 0.05 indicates statistical significance
Table 3: Allele and genotype frequencies of PONI Q192R/L55M and GLOI A111E polymorphisms and their association with BC risk.