Clinico-pathological parameters Total cases n(%) Q192Ra L55Mb Ala111Ec
QQ QR RR LL     LM MM AA AE EE
  144 (100)                  
Age at Diagnosisd                    
≤50 49 (34.0) 40 (81.6) 7 (14.3) 2 (4.1) 26 (53.1) 17 (34.7) 6 (12.2) 0 19 (38.8) 30 (61.2)
51-69 79 (54.9) 56 (70.9) 22 (27.8) 1(12.6) 30 (38.0) 40 (50.6) 9 (11.4) 0 29 (36.7) 50 (63.3)
≥70 16 (11.1) 14 (87.5) 1(6.25) 1 (6.25) 14 (87.5) 1 (6.25) 1 (6.25) 0 8 (50.0) 8 (50.0)
                                pe > 0.05 p = 0.008 p > 0.05
Lymph nodes                    
Positive 34 (23.6) 30 (88.2) 3 (8.8) 1 (2.9) 4 (11.8) 21 (61.8)   9 (26.5) 0 9 (26.5) 25 (73.5)
Negative 110 (76.4) 80 (72.7) 27 (24.5) 3 (27.3) 66 (60.0) 37 (33.6) 7 (6.4) 0 47 (42.7) 63 (57.3)
    p = 0.142 p < 0.001   p > 0.05  
Nuclear grading                    
Low 129 (89.6) 108 (83.7) 18 (13.9) 3 (2.3) 66 (51.2) 48 (37.2) 15 (11.6) 0 56 (43.4) 73 (56.6)
High 15 (10.4) 2 (13.3) 12 (80.0) 1 (6.7) 4 (26.7) 10 (66.7) 1 (6.7) 0 0 15(10.4)
                                    p < 0.001                         p = 0.088      p<0.001    
aGenotypes with Q/R alleles.
bGenotypes with L/M alleles
c Genotypes with A/E alleles
dThe mean ± SD ages are 59.2 ± 9.7 years for cases
e Two-sided χ2 test; p< 0.05 indicates statistical significance
Table 4: Associations between PONI Q192R/L55M and GLOI A111E genotypes according to patients’ age, lymph nodes and nuclear grading.