Figure 5: Extended PPI network. (A) Linker molecules known to interact with both BBs and ADRs were added into the original PPI network of BBs and ADRs. In total, 63 linkers were identified. The color of the node indicates the type of nodes (blue: BB, yellow: ADR, green: BB / ADR, and red: linker). The node size indicates the number of its edge indicating PPI. (B)GSEA results for extended PPI network. The numbers of genes belonging to each manual module were counted and empirical p-values were calculated in the same manner as that used for BB-PPI.