Criteria Score
The number of subjects
NA 0
0<n<50 1
50 ≤ n<100 2
100 ≤ n<150 3
150 ≤ n 4
Age (year old)
NA 0
Welch’s t-value of age range ≥ 2.77* 1
Welch’s t-value of age range<2.77* 2
MMSE score
NA 0
Welch’s t-value of MMSE range<24.15† 1
Welch’s t-value of MMSE range ≥ 24.15† 2
Statistical significance (p-value)
NA 0
0.01<p-value ≤ 0.05 1
0.001<p-value ≤ 0.01 2
0<p-value ≤ 0.001 3
Maximum meta-score 15
Meta-score of each biomarker was calculated by the sum of assigned scores in each criterion. Therefore, maximum meta-score per a single article can be 4+4+2+2+3=15 (the number of subjects for control [4] and AD [4]+age [2]+MMSE score [2]+statistical significance [3]). If one biomarker was reported by multiple articles, the meta-scores evaluated in each article were then added. *2.77 is mean of Welch’s t-value for age range. †24.15 is mean of Welch’s t-value for MMSE range.
Table 2: Criteria of meta-scoring system for BBs of AD.