| Criteria |
Score |
| The number of subjects |
| NA |
0 |
| 0<n<50 |
1 |
| 50 ≤ n<100 |
2 |
| 100 ≤ n<150 |
3 |
| 150 ≤ n |
4 |
| Age (year old) |
| NA |
0 |
| Welch’s t-value of age range ≥ 2.77* |
1 |
| Welch’s t-value of age range<2.77* |
2 |
| MMSE score |
| NA |
0 |
| Welch’s t-value of MMSE range<24.15† |
1 |
| Welch’s t-value of MMSE range ≥ 24.15† |
2 |
| Statistical significance (p-value) |
| NA |
0 |
| 0.01<p-value ≤ 0.05 |
1 |
| 0.001<p-value ≤ 0.01 |
2 |
| 0<p-value ≤ 0.001 |
3 |
| Maximum meta-score |
15 |
|
| Meta-score of each biomarker was calculated by the sum of assigned scores
in each criterion. Therefore, maximum meta-score per a single article can be
4+4+2+2+3=15 (the number of subjects for control [4] and AD [4]+age [2]+MMSE
score [2]+statistical significance [3]). If one biomarker was reported by multiple
articles, the meta-scores evaluated in each article were then added. *2.77 is mean
of Welch’s t-value for age range. †24.15 is mean of Welch’s t-value for MMSE
range. |
| Table 2: Criteria of meta-scoring system for BBs of AD. |
