Gene Degree Gene Degree Gene Degree PDZRN4 4 CTSD* 2 CASP6 2 OBSL1 3 ITIH1* 4 SGOL2 2 RANBP3 4 PALB2 4 CFB* 2 CABLES1 4 CHKB 2 CNOT1 2 LRPAP1 2 OR3A2 2 BCL2 2 SORBS3 3 PKP4 2 KAT5 2 SETX 6 ITGA2 2 TFRC* 2 COL4A5* 2 BBC3 4 APBA2 3 CACNA1I 5 APOA2* 6 EXOC6 4 TLN2 2 CASP1 4 CTSB* 3 DERL1 3 ATM 7 LRP2 2 DAB1 2 NPHS1 4 UBE2I 2 RANBP2 3 GSN* 8 LDB3 4 SCAF1 4 UCHL1 2 APOC3* 3 KLK2 4 C12orf35 4 CFD* 4 CP* 3 CRB1* 4 RYR2 4 SHC3 2 LAMA1* 2 FURIN 2 DGKG 2 PHC3 2 OR2T6 4 KLK3* 9 IGDCC4 5 SH3BP5 4 TFR2 2 AP1M1 6 AKT1 2 FN1* 7 LRP8* 2 KLC1 2

The names of all genes were retrieved from official gene symbol of HPRD.* indicates secreted protein (information about secretion is retrieved from the UniProt database)

Table 4: The list of linker molecules.