Pathway p-Value FDR Gene Symbol
MAPK signaling pathway

6.40E-08

5.65E-06

MKNK2, CACNB4, EGF, HSPA1L, MOS, RASGRF2, MAPK8IP3, CEBPZ, HSPA1A, HSPA1A, KRAS, MAPKAPK5, PTPN7, TNF
Gap junction

1.09E-04

6.33E-04

GNA11, EGF, ADCY2, CDC2, CDK1, KRAS, PDGFD
Cell adhesion molecules (CAMs)

1.12E-04

6.33E-04

NRXN1, HLA-DQA2, HLA-F, HLA-DQA1, HLA-G, PDCD1, PVRL2
p53 signaling pathway

0.002349

0.005206

ATR, GTSE1, CDC2, CDK1, MDM2
Cytokine-cytokine receptor interaction

0.005546

0.010259

EGF, BMP7, FLT4, CCL14, RELT, TNF, TNFSF13B
Notch signaling pathway

0.006421

0.0117

NCOR2, CTBP2, JAG2
GnRH signaling pathway

0.011063

0.017584

GNA11, PLD1, ADCY2, KRAS
T cell receptor signaling pathway

0.011779

0.01834

PDCD1, CARD11, KRAS, TNF
Acute myeloid leukemia

0.011996

0.01856

JUP, KRAS, RUNX1T1
Mismatch repair

0.014568

0.021396

CDC2, MSH2
B cell receptor signaling pathway

0.022695

0.028704

CARD11, FCGR2B, KRAS
Chronic myeloid leukemia

0.022695

0.028704

CTBP2, KRAS, MDM2
Table 1: Pathway analysis of differentially hypomethylated genes associated with low level benzene exposure.