Gene symbol Gene symbol Description betweenness centrality degree Regulation stytle
KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.0377 6 low
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0348 4 low
JUN jun proto-oncogene 0.0261 4 high
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.0239 2 high
RYR3 ryanodine receptor 3 0.020 3 low
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.010 4 high
The degree is defined as the sum of connection strengths with the other network genes. For a gene in the network, the number of source genes of a gene is called the indegree of the gene and the number of target genes of a gene is its outdegree. The character of genes is described by betweenness centrality measures reflecting the importance of a node in a graph relative to other nodes
Table 3: The top 6 significantly methylated genes according to the degree size Supporting Information.