Haplotype (1-2-3) RA, n=538 (%) HC, n=464 (%) P OR (95% CI) C-G-G 80 74 0.03 1.39(1.02-1.89) T-G-G 11 10.6 NS   C-G-A 7 10.6 0.03 0.61(0.38-0.98) C-A-G 1.6 1.7 NS   T-G-A 0.4 1.7 0.03 0.21 (0.02-1.08) T-A-G 0 0.9 0.03 0.00 (0.00-1.30) C-A-A 0 0.4 NS

1-rs1799724, 2-rs1806629, 3- rs361525, RA-Rheumatoid Arthritis, HC- Healthy control, OR- odds ratio, 95% CI -95% confidence interval, P values <0.05 were considered significant.

Table 2: Frequency of TNF-α haplotypes in RA and HC