HR (95% CI) (unadjusted) P-value (unadjusted) HR (95% CI) (adjusted) P-value (adjusted)
2a CRPC        
ERG expression/PTEN deletion*/GS≥8 19.43 (1.73-218.17) 0.016 40.445 (2.94-557.32) 0.006
2b PCa specific death        
ERG expression/PTEN deletion*/ GS≥8 17.99 (1.57-205.66) 0.020 64.21 (4.22-976.52) 0.003
ERG expression/EZH2 expression/PTEN deletion** ns   40.70 (2.00-827.98) 0.016
ERG expression/PTEN deletion** ns   44.05 (2.01-964.37) 0.016
* Hetero-or  homozygous deletion
** Heterozygous deletion
Adjusted for PSA at diagnosis, T-stage, Gleason score, age at diagnosis, calendar year of diagnosis GS=Gleason score, ns=not significant
Table 2: Combination of markers and clinical outcome