4 Subgroups Subgroup 1 Subgroup 2 Subgroup 3 Subgroup 4
Molecular status Complete normalisation Partial normalisation Same profile New rearrangements
33 patients 4 patients
3 GRs
1 PR
15 patients
8 GRs
7 PRs
7 patients
2 GRs
5 PRs
7 patients
3 GRs
4 PRs
 
5-year OS
5-year EFS
100%
100%
92%
80%
43%
29%
15%
15%
p= 0.0003
p=0.002
p=0.001
p=0.0001
p=0.0001
Alive
Dead
4
0
13
2
3
4
1
6
Median survival
(months)
event
155
no event
119
2 events
39.5
4 events
24.5
6 events
Table 2: Characteristics of the 4 subgroups identified with the allelotyping analyses comparing biopsy and tumor molecular rearrangements.