MicroRNAs New miRBase annotations Number of subjects Number of studies with fold changes indications Fold changes (obeses vs. non obeses) References miR-221 miR-221-3p 186   -3.22 ;-5.94 Ortega [27]; Prats-Puig[29] miR-142-3p miR-142-3p 186 2 3.19;+2.79 Ortega [27]; Prats-Puig[29] miR-125b miR-125-5p 186 2 -3.31 ;-1.93 Ortega  [27]; Prats-Puig[29] miR-140-5p miR-140-5p 186 2 2.59;+1.41 Ortega [27]; Prats-Puig[29] miR-222 miR-222-3p 186 2 1.92;+1.62 Ortega [27];Prats-Puig[29] miR-103 miR-103a-5p 61 2 -2.57 Karolina [46] 24 1 decreased Murri[35] miR-21 miR-21-5p 85   decreased Ortega [27];Murri[35] miR-423-5p miR-423-5p 125   1.91 Prats-Puig[29] 61 1 -5.9 Ortega [27] miR-532-5p miR-532-5p 125   1.91 Prats-Puig[29] 61 1 -2.19 Ortega [27] miR-122 miR-122-5p 248 1 1.6; +3.07 Prats-Puig[29]; Wang [63] 61 2 decreased Ortega [27] miR-130b miR-130b-3p 125 1 1.5 Prats-Puig[29] 61 1 -3.14 Ortega [27]

Table 1: Circulating miRNAs differentially expressed between obese vs. non obese subjects, identified at least in 2 studies.