miR-320a miR-320a 120 3 +1.93;+2.33;+1.37 Karolina [45]; Karolina [46]; Wang [30] miR-150 miR-150-5p 120 3 +2.17;+1.57;+1.46 Karolina [45]; Karolina [46]; Wang [30]     160   decreased Zampetaki     46 2 +1.51;+1.28 Karolina [45]; Wang [30] miR-126 miR-126-3p 106 1 -1.541;-1.932 Ortega [28]*     518   decreased Zampetaki; Liu [42]; Zhang [43] mir-197 miR-197-3p 58 1 -1.35 Karolina [45]     160   decreased Zampetaki miR-20b miR-20b-5p 13 1 -2.33 Karolina [45]     160   decreased Zampetaki miR-146a miR-146a-5p 127   increased Kong [47]; Rong[48]     29 1 -2.54 Karolina [45] miR-142-3p miR-142-3p 106 2 +1.69;+6.681;+4.822 Karolina[45]; Ortega [28]* miR-222 miR-222-3p 106 2 +1.86;+2.121;+3.072 Karolina[45]; Ortega [28]* miR-192 miR-192-5p 87 2 +2.48;+1.86 Karolina [45]; Karolina [46]     65 1 -3.511; ns2 Ortega FJ 2014* miR-17 miR-17-5p 71 2 -1.59;-2.42 Karolina [45]; Karolina [46] miR-652 miR-652-3p 71 2 -2.06;-1.75 Karolina [45]; Karolina [46] miR-29a miR-29a-3p 13 1 2,46 Karolina [45]     53   increased Kong [47] miR-27a miR-27a-3p 50 2 +2.28;+2.53 Karolina [45]; Karolina [46] miR-375 miR-375 13 1 2 Karolina [45]     257   increased Kong [47]; Higuchi [44] miR-29b miR-29b-3p 46 2 +2.38;+1.31 Karolina [45]; Wang [87]     49   decreased Zampetaki miR-15a miR-15a-5p 46 2 +2.15;+1.41 Karolina [45]; Wang [87]     160   decreased Zampetaki miR-21 miR-21-5p 33 1 1.27 Wang [87]     160   decreased Zampetaki miR-24 miR-24-3p 33 1 1.2 Wang [87]     160   decreased Zampetaki miR-125b miR-125b-5p 13 1 1.85 Karolina [45]     106 1 -1.861; -1.862 Ortega [28]* miR-30d miR-30d-5p 37   increased Kong [47]     13 1 -2.89 Karolina [45]

Table 2: Circulating miRNAs differentially expressed between T2DM patients vs. controls, identified at least in 2 studies *In the study of Ortega et al. 2014, 2 fold changes are calculated: DT2 vs. non-obese controls 1, and DT2 vs. obese controls 2.