MicroRNAs Obese vs.controls Pre-diabetes vs. controls T2DM vs.controls Interventions No.of studies Regulations No.of studies Regulations No.of studies Regulations Physical Activity Metformin Bariatric surgery miR-146a     1 + 2 + + (2), (6)   3 1 - -7     miR-142-3p 2 +     1 -   4 -3 miR-222 2 + 1 - 2 + 2 -4   miR-125b 2 -     1 +       1 -     -3 miR-140-5p 2 +     1 +   -4 -3 miR-21 2 -     1 +       2 - 2   3 miR-221 2 - 1 + 1 + 2   3     -7     miR-126 1 + 1 1 + - 2 + + (1) (6)     4 -       miR-423-5p 1 1 + - 1 - 1 -     3           miR-130b 1 1 + -     1 +     3           miR-192     1 +     -5 4   miR-193b     1 -     -5

Table 3: Impact of lifestyle or therapeutic interventions on the circulating levels of miRNAs in blood of T2DM, obese or pre-diabetic patients [27,28,37,39,52].