MicroRNAs Obese vs.controls Pre-diabetes vs. controls T2DM vs.controls Interventions
No.of studies Regulations No.of studies Regulations No.of studies Regulations Physical Activity Metformin Bariatric surgery
miR-146a     1 + 2 + + (2), (6)   3
1 - -7    
miR-142-3p 2 +     1 -   4 -3
miR-222 2 + 1 - 2 + 2 -4  
miR-125b 2 -     1 +      
1 -     -3
miR-140-5p 2 +     1 +   -4 -3
miR-21 2 -     1 +      
2 - 2   3
miR-221 2 - 1 + 1 + 2   3
    -7    
miR-126 1 + 1
1
+
-
2 + + (1) (6)    
4 -      
miR-423-5p 1
1
+
-
1 - 1 -     3
         
miR-130b 1
1
+
-
    1 +     3
         
miR-192     1 +     -5 4  
miR-193b     1 -     -5    
Table 3: Impact of lifestyle or therapeutic interventions on the circulating levels of miRNAs in blood of T2DM, obese or pre-diabetic patients [27,28,37,39,52].