Red sea organisms Anticancer agent Cell line IC50  (μM) Reference cyanobacteriumMoorea Lyngbyatoxin A  Aplysiatoxin Debromoaplysiatoxin  HeLa  HeLa  HeLa  0.0092 13.03 3.03 [161] CyanobacteriumMooreaproducens Apratoxin H Apratoxin A sulfoxide NCI-H460  NCI-H460  0.0034 0.0899 [162] cyanobacteriumLeptolyngbya sp. Grassypeptolides D Grassypeptolides E  HeLa  HeLa 0.335 0.192 [163] Sinulariapolydactyla 24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate Durumolide C HepG2 HCT  HepG2 6.1  8.2 1.0 [164] Laurenciaobtusa Teuhetenone  MCF-7 22  [165] Sarcophytonglaucum Sarcophinediol Sarcotrocheliol acetate HepG2 HepG2 18.8 ± 0.07  19.9 ± 0.02 [166] Deoxosarcophine Sarcotrocheliol acetate Sarcotrocheliol MCF-7 MCF-7 MCF-7 9.9 ± 0.03 2.4 ± 0.04 3.2 ± 0.02 6-oxogermacra-4(15),8,11-triene Sarcophinediol Deoxosarcophine HCT116  HCT116  HCT116  29.4 ± 0.03, 19.4 ± 0.02 25.8 ± 0.03 Sarcophytonglaucum Sarcophytolol Sarcophytolide C Aromadendrene HepG2 HepG2 HepG2 20 μM 20 μM 20 μM [167]     Sarcophytolide B Sarcophytolide C MCF-7 MCF-7 25 ± 0.0164 29 ± 0.030 10(14)aromadendrene PC-3 9.3 ± 0.164 Sarcophytonauritum Sarcophine 2-epi-sarcophine (+)-7a,8b dihydroxydeepoxysarcophine (1R,2E,4S,6E,8R,11R,12R)-2, 6-cembradiene-4,8,11,12-tetrol HepG2 HepG2 HepG2 HepG2 23 ± 0.12 20.6 ± 0.31 11 ± 0.22 21.1 ± 0.16 [168]   Sarcophine 2-epi-sarcophine (+)-7a,8b-dihydroxydeepoxysarcophine (1R,2E,4S,6E,8R,11R,12R)-2, 6-cembradiene-4,8,11,12-tetrol MCF-7 MCF-7 MCF-7 MCF-7 22.4 ± 0.22 19.7 ± 0.24 18.4 ± 0.16 20 ± 0.12 Petrosiasp. (3_,7_,9_trihydroxycholest-5-en (3,7-dimethyl-2-(methylamino)-3H-purin-6(7H)-one (N-((3S,E)-1,3-dihydroxytetracos-4-en-2-yl)stearamide MCF-7 MCF-7 MCF-7 153.0 ± 0.012 130.0 ± 0.017 23.0 ± 0.017 [169] (3_,7_,9_trihydroxycholest-5-en (3,7-dimethyl-2-(methylamino)-3H-purin-6(7H)-one (N-((3S,E)-1,3-dihydroxytetracos-4-en-2-yl)stearamide HepG2 HepG2 HepG2 230.0 ± 0.031 145.0 ± 0.120 20.0 ± 0.120 Sarcophytonglaucum 7beta-Acetoxy-8alpha-hydroxydeepoxysarcophine HepG2 HCT-116 HeLa 3.6 2.3 6.7 [170]   Siphonochalinasiphonella Neviotine-C PC-3 A549 7.9 ± 0.120 8.9 ± 0.010 [171]   Cnidarian Litophytonarboreum Extract U-937        6.5±2.3 [172]   Sarcophytontrochliophorum Extract HeLa 5.2±1.2 [172]   Hyrtios erectus Hyrtioerectine A -- moderately cytotoxic [173]   Palythoatuberculosa Palysterol G MCF-7 Induce apoptosis [174]   Siphonochalinasiphonella Sipholenone A MCF-7 HepG-2 3.0 2.8 [175]   Callyspongiaaff. implexa Gelliusterol E Callimplexen A β-sitosterol chlamydial inclusions 2.3 [176]   Sargassum sp. Fucoxanthin MCF-7 11.5 [177]   Spheciospongiavagabunda (R)-20-hydroxy-N-[(2S,3S,4R)-1,3,4-tri-hydroxypentacosan-2-yl] octadecanamide (R,Z)-20-hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxytricosan-2-yl) non-adec-10-enamide HepG2& MCF-7 HepG2& MCF-7 24.7& 6.8   21.3& 29.8l [178]

Table 3: Red sea organisms based anticancer agent and its IC50 value against different cell lines.