| Progression of tumor |
| Mechanism |
Mediator (s) |
| Enhancement of growth |
Growth factors (EGF, PDGF, TNF-b)
Cytokines(IL-6, TNF-α)
L-arginine derived polyamine |
| Enhanced Angiogenesis |
Through production of various cytokines (GM-CSF, TGF-α, TGF-β, IL-1, IL6,IL8)
Prostanoids (Procogulant activity) |
| Invasion and Dissemination |
Cytokines (TNF-α, IL1)
Lytic enzymes (Metaloproteases and plasminogen activator) |
| Immunosuppression |
Prostanoids (PGE2), cytokines(IL-10), and other mediators (TNF-b) |
| Downregulation of the tumor cells |
| Direct cellular cytotoxicity |
Cell to cell contact |
| Antibody-dependent celluar cytotoxicity |
Fc-receptor(CD16) |
| Secretory products (cytotoxic/cytostatic) |
Ecosanoids (PGs, LTS)
Cytokines (IL-1, TNF-α)
Free redicals (R10, NO) |
| Macrophase induces apoptosis |
TNF-α, IL-10, R-10, NO |
|
