Parameter Oct2 + / BCL6 + / IRF8 + / OCAB + / PU.1 + /
Total (%) Total (%) Total (%) Total (%) Total (%)
Sex
Male 34/39 (87.2) 22/39 (56.4) 22/39 (56.4) 18/39 (46.1) 11/39 (28.2)
Female 30/34 (88.2) 18/34 (52.9) 22/34 (64.7) 21/34 (61.7) 7/34 (20.6)
Age
≤ 60 31/36 (86.1) 20/36 (55.5) 21/36 (58.3) 21/36 (58.3) 8/36 (22.2)
> 60 33/37 (89.2) 20/37 (54.0) 23/37 (62.2) 18/37 (48.6) 10/37 (27.0)
DLBCL Stage
I 14/17 (82.4) 11/17 (64.7) 14/17 (82.4) 14/17 (82.4) 14/17 (82.4)
II 23/26 (88.5) 14/26 (53.8) 23/26 (88.5) 23/26 (88.5) 23/26 (88.5)
III 13/15 (86.7) 6/15 (40.0) 13/15 (86.7) 13/15 (86.7) 13/15 (86.7)
IV 13/14 (92.9) 8/14 (57.1) 13/14 (92.9) 13/14 (92.9) 13/14 (92.9)
LDH serumlevels
Normal 13/15 (86.7) 8/15 (53.3) 10/15 (66.7) 6/15 (40.0) 2/15 (13.3)
Up 20/21 (95.2) 10/11 (90.9) 14/21 (66.7) 12/21 (57.1) 4/21 (19.0)
Extranodaldisease
Absent 22/27 (81.5) 14/27 (51.8) 15/27 (55.5) 12/27 (44.4) 2/27 (7.4)
Present 27/29 (93.1) 15/29 (51.7) 18/29 (62.0) 20/29 (69.0) 9/29 (31.0)
B symptoms
Absent 42/49 (85.7) 31/49 (63.3) 27/49 (55.1) 27/49 (55.1) 15/49 (30.6)
Present 21/23 (91.3) 8/23 (34.8) 16/23 (69.6) 11/23 (47.8) 3/23 (13.0)
Pearson Chi Square Test: NS
Note: No association was found between Oct2, BCL6, IRF8, OCAB or PU.1 expression and the clinical and pathological parameters currently considered as relevant in DLBCL patients. The table shows the lack of correlation with sex, age, DLBCL stage, serum LDH level, extranodal disease and B symptoms, as examples. The entire set of data (clinical, pathological, phenotype markers and treatments) was collected from patient charts and analyzed in the same way applying the Chi Square Test. Other parameters included were DLBCL molecular phenotype (GCB and non-GCB), topography of lymph nodes involved, treatments received and patient response to therapy.
Table 2: No association was found between Oct2, BCL6, IRF8, OCAB or PU.1 expression and the clinical and pathological parameters currently considered as relevant in DLBCL patients. The table shows the lack of correlation with sex, age, DLBCL stage, serum LDH level, extranodal disease and B symptoms, as examples. The entire set of data