Figure 2: PLS-DA scores and loadings plots based upon UPLC/QTof data from serum analysis. (A) PLS-DA scores plot showing metabolomic changes in UPLC/QTof-MS positive mode data of serum analysis from animals treated with vehicle, 100 mg APAP/kg body weight or 1250 mg APAP/kg body weight at all time points. (B) The corresponding loadings used Pareto scaling. The labeled metabolites are significantly altered and responsible for group separations.