Figure 6: Metabolite and gene expression changes in bile acid metabolism pathway. Observed metabolite changes and gene expression changes mapped onto bile acid metabolism pathway perturbations in the HD group at all time points. Bile acids levels in blood were from profiling (LC/MS and LC/MS/MS), and/or from targeted analysis (TQ). Gene expression analysis was from liver tissue. Both metabolite and gene expression changes were shown as fold changes in the treated groups compared to their corresponding controls. *denotes that LC/MS/MS cannot differentiate glycochenodeoxycholic acid from glycodeoxycholic acid, or taurochenodeoxycholic acid from taurodeoxycholic acid.