metabolites

retention time

P valuea

A(healthy controls)

B(cancer)

Rb

lactic acid

7.069

0.000

0.0022±0.0002

0.0031±0.0008

0.41

glycerol

12.373

0.038

0.0145±0.0069

0.0086±0.0054

-0.41

butanedioic acid

13.801

0.014

0.0005±0.0001

0.0004±0.0001

-0.20

L-serine

15.134

0.000

0.0014±0.0004

0.0006±0.0003

-0.57

L-threonine

15.938

0.002

0.0011±0.0002

0.0006±0.0004

-0.45

citric acid

28.678

0.026

0.0045±0.0013

0.0034±0.0012

-0.24

hexadecanoic acid

34.543

0.000

0.0665±0.0075

0.1213±0.0282

0.82

aP values were calculated based on Mann-Whitney test (significance at P<0.05). bR value was calculated from the arithmetic mean values of each group. R=(B-A)/A. R with a positive value indicates a relatively higher concentration present in cancer group while a negative value means a relatively lower concentration as compared to the healthy controls.
Table 3a: List of different metabolites identified in healthy controls and gastric cancer patients.