metabolites

retention time

P valuea

A(non-invasive cancers)

B(invasive/metastasic cancers)

Rb

glycerol

12.373

0.045

0.0119±0.0052

0.0071±0.0049

-0.40

butanedioic acid

13.801

0.027

0.0005±0.0001

0.0003±0.0001

-0.40

L-serine

15.134

0.003

0.0009±0.0002

0.0005±0.0003

-0.44

L-threonine

15.938

0.005

0.0010±0.0002

0.0004±0.0004

-0.60

L-proline

20.391

0.082

0.0041±0.0013

0.0029±0.0011

-0.29

myo-inositol

35.389

0.027

0.0029±0.0006

0.0039±0.0011

0.34

aP values were calculated based on Mann-Whitney test (significance at P<0.05). bR value was calculated from the arithmetic mean values of each group. R=(B-A)/A. R with a positive value indicates a relatively higher concentration present in invasive/metastasic cancers while a negative value means a relatively lower concentration as compared to the non-invasive cancers.
Table 3b: List of different metabolites identified in non-invasive and invasive/metastatic gastric cancer patients.