Main findings




Esposito et al. (17)

Ki67 and PCNA

There was no correlation of Ki67 and PCNA with TNM staging, nor with the degree of malignancy.

Bettendorf, Herrmann (16)


No correlation could be established between the Ki-67 immunostaining and histological and clinical parameters. Highly significant inverse correlation was found between the Ki-67, the stroma/tumour proportion and the degree of  keratinization.

Tumuluri et al. (3)


Well-differentiated tumors having the lowest mean Ki-67 immunostaining.

Kurokawa et al. (14)

Ki-67 and p53

Overexpression of Ki-67 and p53 at the deep tumor invasive front of OSCC is associated with histologic grade of malignancy.

Myong et al. (19)

PCNA and Ki67

Immunostaining increased in tumors with cervical lymph node metastasis.  Ki-67 and clinical stage as independent prognostic factor in evaluating survival in patients with OSCC.

Kim et al. (18)


The higher immunoexpression of Ki-67 was associated with a worse survival rate, suggesting that may be useful in predicting the prognosis of OSCC.

Watanabe et al. (22)

Ki-67, PCNA and Cyclin B1

The expression of Ki-67 and cyclin B1 were significantly stronger in OSCC than normal oral mucosa. The levels of Ki-67 were higher in floor of the mouth. Cyclin B1 showed a positive correlation with histological grade. PCNA was higher in the normal oral mucosa than in the OSCC.

Angadi et al. (26)

Cyclin D1

Overexpression of cyclin D1 in OSCC. High immunostaining was associated with a histological grade of malignancy.

Thomson et al. (29)  

Cyclin A

High immunostaining was associated with a worse clinical outcome suggests a role for cyclin A as a predictive tool in the clinical behavior of the OSCC.

Wang et al. (21)          

Cyclin D1, ERK1/2 e Ki67

The expression of Ki67, ERK1/2 and cyclin D1 was significantly stronger in OSCC than in normal oral mucosa. Positive correlations were observed between ERK1/2 and cyclin D1, and between ERK1/2 and Ki67, indicating that the MAP kinase pathway is involved in the OSCC.

Mishra et al. (28)                 

Cyclin D1

Percentage of immunopositivity and intensity of labeling for cyclin D1 was  significantly higher in poorly differentiated compared to well differentiated OSCC, suggesting an association between expression of cyclin D1 with the severity of dysplasia and carcinomas.

Table 1: Cell proliferative activity in oral squamous cell carcinoma.