| Apoptosis and cell senescence |
APAF1, BAD, BAX, BCL2, BCL2L1 (bcl-X), BIRC5 (Survivin),
CASP8, CASP9, CFLAR, TERT, TNFRSF1A, TNFRSF6 (Fas), TNFRSF10B (DR5), TNFRSF12 (DR3) |
| Cell cycle control and DNA Damage Repair: |
ATM, BRCA1, BRCA2, CCND1 (cyclin D1), CCNE1
(cyclin E1), CDC25A, CDK4, CDKN1A (p21Waf1), CDKN1B (p27Kip1), CDKN2A (p16Ink4),
CHEK2 (chk2/Rad53), MDM2, PRKDC (DNA-PK), RB1, TP53 (p53) |
| Signal transduction molecules and transcription factors |
AKT1, CTNNB1 (b-catenin), ERBB2, ETS2, FOS, JUN, MAPK14 (p38 MAPK), MAP2K1 (MEK), MYC, NFKB1 (NFkB), NFKBIA (IkBa), PIK3CB (PI3K p110b), PIK3R1 (PI3K p85a), RAF1, RASA1, SRC |
| Adhesion |
CD44, CDH1 (E-cadherin), ICAM1, ITGA1 (integrin a1), ITGA2 (integrin a2), ITGA3 (integrin a3), ITGA4 (integrin a4), ITGA5 (integrin a5), ITGA6 (integrin a6), ITGAV (integrin aV), ITGB1 (integrin b1), ITGB3 (integrin b3), ITGB5 (integrin b5), MICA (MUC18), NCAM1 |
| Invasion and metastasis |
KISS1, KAI1, MMP1 (collagenase-1), MMP2 (gelatinase A), MMP9 (gelatinase B), MTA1, NME4 (Nm23), PLAU, PLAUR, SERPINB2 (PAI2), SERPINB5 (maspin), SERPINE1 (PAI1), TIMP1 |
| Angiogenesis |
ANGPT1 (angiopoietin-1), ANGPT2 (angiopoietin-2), COL18A1 (endostatin), EGF, EGFR, FGF2 (bFGF), FGFR2, FLT1 (VEGFR), HGF, IFNA1 (IFNa), IFNB1 (IFNb), IGF1, IL8, PDGFA, PDGFB, TEK (tie-2), TGFB1, TGFBR1 (ALK-5), THBS1 (thrombospondin-1), THBS2 (thrombospondin-2), TNF, VEGF. |
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