Blood biomarkers Lung cancer
histological types
Verification methods Sensitivity and specificity of biomarkers Blood biomarkers in other disease Reference
KLKB1 ADC Western blot - - [14]
SAA ADC, SQLC, SCLC Western blot, ELISA, Immunohistochemistry, In vivo assay, MRM - Pancreatic, ovarian,  renal and colorectal cancer [17,18,85-88]
HP-β chain ADC, SQLC, SCLC Western blot, ELISA Sensitivity : 82.6%
Specificity : 63.2%
Oral, breast, liver, ovarian pancreatic  colorectal and bladder cancer [20-24]
C9 SQLC, SCLC Western blot, protein arrays, Hybrid AAL lectin ELISA Sensitivity : 53%
Specificity : 89%
Cervical, gastric, colorectal and breast cancer [27,89-92]
IGFBP-2 and anti-IGFBP-2 autoantibody ADC, SQLC ELISA, Immunohistochemistry Sensitivity : 85.7%
Specificity : 57.5%
glioma, colorectal, prostate, ovarian  and breast cancer [29-34]
PRX1 ADC, SQLC, SCLC 2-DE screening, Western blot - - [42]
CD105 NSCLC ELISA - Prostate, breast, colorectal and liver cancers [48-52,93]
Pgrmc1 ADC, SQLC Western blot, Immunohistochemistry, In vitro assay - ovarian, breast cancer [56,59]
ProGRP SCLC ARCHITECT ProGRP assay Sensitivity : 86.5%
Specificity : 95%
chronic renal failure [64,94]
Ciz1 ADC, SQLC, SCLC Western blot, Immunohistochemistry, In vitro and In vivo assays Sensitivity : 95%
Specificity : 74%
- [69]
MMP1 All ELISA, Immunohistochemistry - colorectal, esophageal, pancreatic, gastric, breast cancer and malignant melanoma [72-77]
uPAR NSCLC Three time-resolved fluoroimmunoassays (TR-FIA) - Colorectal, prostate, ovarian cancer and myeloma [83,95-98]
Table 1: Recently reported potential lung cancer serum/plasma biomarkers.