OVARIAN CANCER
TYPE I
TYPE II
ADVANCED
NON ADVANCED
ALL
PM
M
ALL
PM
M
ALL
PM
M
ALL
PM
M
SENSITIVITY
[%]
ROMA
78.9
60
85.7
95.6
90.9
97.1
96.7
91.7
98
63.6
55.6
69.2
ROMA1
76.3
60
82.1
93.3
90.9
94.1
95.1
91.7
95.9
59.1
55.6
61.5
HE4
65.8
50
71.4
91.1
90.9
91.2
90.2
91.7
89.8
52.4
44.4
53.8
CA125
86.8
70
92.9
93.3
100
91.2
96.7
100
95.9
72.7
66.7
76.9
SPECIFICITY
[%]
ROMA
88.5
91.6
80.6
88.5
81.8
80.6
88.5
91.6
80.6
88.5
91.6
80.6
ROMA1
95.4
96.8
91.7
95.4
96.8
91.7
95.4
96.8
91.7
95.4
96.8
91.7
HE4
87.8
89.5
83.3
87.8
89.5
83.3
87.8
89.5
83.3
87.8
89.5
83.3
CA125
72.5
71.6
75
72.5
71.6
75
72.5
71.6
75
72.5
71.6
75
PPV
[%]
ROMA
66.7
42.9
77.4
74.1
55.6
82.5
79.7
64.7
87.3
48.3
38.5
56.3
ROMA1
82.9
66.7
88.5
87.5
76.9
91.4
90.7
78.6
94
68.4
62.5
72.7
HE4
61
33.3
76.9
72
50
83.8
77.5
52.4
88
40.7
28.6
53.8
CA125
52.2
20.6
74.3
53.8
28.9
77.5
37.9
30.8
83.9
30.8
18.2
52.6
NPV
[%]
ROMA
93.5
95.6
87.9
98.3
98.9
96.7
98.3
98.9
96.7
93.5
95.6
87.9
ROMA1
93.3
95.8
86.8
97.7
98.9
94.3
97.7
98.9
94.3
93.3
95.8
86.8
HE4
89.9
50
78.9
96.6
91
90.9
95
98.8
85.7
52.4
94.4
83.3
CA125
74.2
95.8
93.1
96.9
100
90
97.9
100
93.1
94.1
95.8
90
All – PM+M; PM – Premenopause; M – Postmenopause ; ROMA 1 – risk stratification based on cutoff points determined by authors
Table 4:
Sensitivity, specificity, PPV, and NPV of CA125, HE4, and ROMA for identification of type and stage of ovarian cancer.
