E6/E7 HPV mRNA test (%) Histopathology§ (%) Negative CIN2- CIN2+ Total Negative 17 (85) 39 (68.4) 6 (33.3) 62 (65.3) Positive* 3 (15) 18 (31.6) 12 (44) 33 (34.7) Total 20 57 18 95 *E6/E7 mRNA positive result: positivity for one or more HPV genotypes (16,18,31,33,35) included in the test §The final histological diagnosis was based on the highest CIN grade present in the tissue For the purpose of the study, histological results were grouped into: CIN2- or-greater (CIN2+, including CIN2, CIN3 and squamous cell carcinoma), CIN2- (including CIN1), and negative for dysplasia (including inflammatory and reactive findings) (p<0.01)

Table 2: Relationship between histological diagnosis and E6/E7 mRNA test results, in female population.