| 
      
        |  |  |  | Control | Cancer | p value |  
        | Biomarker | Units | Serum/  plasma | median (range) | median (range) | cancer vs control |  
        |  |  |  |  | all    cancers |  |  
        | PKM2 | U/ml | plasma | 21.02    (11.26 - 73.3) | 30.71    (5.81 - 98.80) | 0.0006 |  
        | IL8 | pg/ml | serum | 11.26    (4.36 - 49.89) | 15.77    (3.71 - 103.5) | 0.0006 |  
        | IL6 | pg/ml | serum | 1.84    (0.95 - 55.80) | 1.355    (0.93 - 4.740) | 0.0006 |  
        | IGFBP2 | ng/ml | serum | 490.5    (188.7 - 1583) | 699.2    (163.3 - 3698) | 0.0011 |  
        | Mac2BP | ng/ml | serum | 7126    (3918 - 20150) | 8350    (4290 - 40870) | 0.0012 |  
        | VEGFA | pg/ml | plasma | 48.69    (31.42 - 387) | 78.96    (33.29 - 910.1) | 0.0013 |  
        | TGFB1 | pg/ml | plasma | 6034    (2070 - 21122) | 8794    (1846 - 64230) | 0.005 |  
        | M65 | U/L | serum | 312.6    (143.3 - 783.2) | 358.4    (132.8 - 1032) | 0.0051 |  
        | IGF2 | ng/ml | serum | 1399    (792.3 - 2230) | 1221    (421.1 - 1864) | 0.0052 |  
        | TIMP1 | ng/ml | plasma | 74.89    (42.53 - 131.3) | 84.31(49.9    - 359.6) | 0.0062 |  
        | TIMP1 | ng/ml | serum | 172.8    (74.3 - 314.4) | 193.8    (98.6-449.4) | 0.0129 |  
        | MMP1 | pg/ml | serum | 2090    (258 - 14300) | 3350    (249 - 56000) | 0.0226 |  
        | OPN | pg/ml | plasma | 4980    (868 - 29600) | 7410    (425 - 297000) | 0.033 |  
        | TNF-alpha | pg/ml | serum | 7.55    (1.55 - 13.21) | 7.85    (3.09 - 26.67) | 0.1092 |  
        | TIMP2 | ng/ml | serum | 82.5    (59.2 - 106.2) | 77.6    (47.3 - 159.4) | 0.1149 |  
        | CEACAM6 | ng/ml | plasma | 1.62    (0.60  - 3.54) | 1.63    (0.60 - 7.99) | 0.1344 |  
        | MIP-1beta | pg/ml | serum | 77.00    (37.30 - 369.0) | 66.95    (35.8 - 1510) | 0.1355 |  
        | Dkk3 | pg/ml | plasma | 58895    (37232 - 78500) | 56473    (27726 - 75779) | 0.3046 |  
        | ENA-78 | pg/ml | serum | 1275    (302 - 5180) | 1240    (264 - 4450) | 0.4717 |  
        | MMP3 | pg/ml | serum | 13250    (2280 - 37600) | 11100    (2600 - 55500) | 0.5033 |  
        | TIMP2 | ng/ml | plasma | 90.71    (64.06 - 129.7) | 90.86    (53.78 - 172.3) | 0.6593 |  
        | MCP1 | pg/ml | serum | 233.5    (80 - 526) | 237.5    (20.3 - 795) | 0.7915 |  
        | MMP8 | pg/ml | serum | 8720    (1510 - 21600) | 8190    (1490 - 50600) | 0.9344 |  
        | M30 | U/L | serum | 178.8    (85.7 - 500.1) | 173.4    (87.17 - 901.6) | 0.9791 |  |