AUC (95% CI) p value Sensitivity (%) at 95% specificity Cut off value (95% specificity)
IL8 0.68 (0.59 - 0.77) 0.0006 38 >21.86
Mac2BP 0.67 (0.58 - 0.76) 0.0009 35 >9304
TIMP1 (plasma) 0.64 (0.55 - 0.73) 0.0061 33 >110.5
OPN 0.61 (0.52 - 0.70) 0.0329 31 >11800
TIMP1 (serum) 0.63 (0.54 - 0.72) 0.0133 28 >232.0
IL6 0.70 (0.61 - 0.80) 0.0002 27 >2.895
M65 0.66 (0.56 - 0.75) 0.0016 26 >472.4
IGFBP2 0.67 (0.57 - 0.76) 0.0008 25 >1225
TIMP2 (serum) 0.58 (0.48 - 0.67) 0.1144 25 <64.67
TIMP2 (plasma) 0.52 (0.43 - 0.62) 0.6578 24 <74.65
IGF2 0.64 (0.55 - 0.73) 0.0040 23 <1040
VEGFA 0.67 (0.58 - 0.77) 0.0005 23 >132.5
CEACAM6 0.58 (0.48 - 0.67) 0.1340 22 >2.558
TGFB1 0.65 (0.56 - 0.74) 0.0027 22 >16195
TNF-alpha 0.58 (0.49 - 0.69) 0.1088 20 >11.51
PKM2 0.70 (0.60 - 0.79) 0.0001 19 >60.39
Dkk3 0.50 (0.41 - 0.60) 0.9502 18 <42184
MMP1 0.62 (0.52 - 0.71) 0.0226 15 >9130
M30 0.51 (0.41 - 0.61) 0.8417 13 >374.2
MMP8 0.51 (0.41 - 0.61) 0.7808 12 >18650
ENA-78 0.54 (0.44 - 0.64) 0.4705 10 <488.0
MIP-1beta 0.56 (0.46 - 0.66) 0.2245 9 <26.35
MMP3 0.53 (0.44 - 0.63) 0.5744 7 <5460
MCP1 0.51 (0.41 - 0.61) 0.7899 6 >416.0
AUC: Area under the receiver operator characteristic curve
Table 3: Sensitivity of biomarkers at 95% specificity.