Marker Other name Function Role in colon tumorigenesis References
Lgr5  - Unknown Prognostic factor, adenoma formation


Wnt activity  - Signalling pathway Normal colon-adenoma transition, stem phenotype maintenance


CD44 H-CAM Cell adhesion, hyaluronic acid receptor Colony formation, xenografts growth, prognostic factor, correlation with tumor stage


CD326 EpCAM Cell adhesion Tumor budding, metastatization


Msi-1   - RNA-binding protein Association with tumor stage


ALDH-1   - Detoxifyng enzime Resistance to alkylating agents, prognostic factor


CD26 DPP4 Cell surface glycoprotein Metastatization


Eph B2   - Wnt target gene Cell compartimentalization


CD166 ALCAM Cell adhesion Prognostic factor


CD133 Prominin-1 Cell motility and iron metabolism Prognostic factor


CD29 Integrin β1 subunit Cell adhesion Colony formation


CD24 HSA Cell adhesion Clonogenic ability, multilineage potential, correlation with invasiveness and survival


Table 1: Molecules expressed by colorectal cancer stem cells.