Marker Other name Function Role in colon tumorigenesis References
Lgr5  - Unknown Prognostic factor, adenoma formation

[10]

Wnt activity  - Signalling pathway Normal colon-adenoma transition, stem phenotype maintenance

[20]

CD44 H-CAM Cell adhesion, hyaluronic acid receptor Colony formation, xenografts growth, prognostic factor, correlation with tumor stage

[33,35]

CD326 EpCAM Cell adhesion Tumor budding, metastatization

[34]

Msi-1   - RNA-binding protein Association with tumor stage

[36]

ALDH-1   - Detoxifyng enzime Resistance to alkylating agents, prognostic factor

[37,40]

CD26 DPP4 Cell surface glycoprotein Metastatization

[38]

Eph B2   - Wnt target gene Cell compartimentalization

[39]

CD166 ALCAM Cell adhesion Prognostic factor

[40]

CD133 Prominin-1 Cell motility and iron metabolism Prognostic factor

[40,43,44]

CD29 Integrin β1 subunit Cell adhesion Colony formation

[41]

CD24 HSA Cell adhesion Clonogenic ability, multilineage potential, correlation with invasiveness and survival

[41,42]

Table 1: Molecules expressed by colorectal cancer stem cells.