Figure 1: A. Serum Dkk–3 protein levels measured by ELISA were decreased in CRC patients compared to healthy controls (p=0.0003). B Serum Dkk–3 protein levels did not significantly differ between CRC disease stages. However, CRC patients with stage C tumours had significantly decreased serum Dkk–3 levels compared to healthy controls (p<0.01). C. Female CRC patients had significantly lower serum Dkk–3 levels than healthy females (p=0.024). D. Likewise, male CRC patients had significantly lower serum levels than healthy males (p=0.005). Individual results are indicated by scatter plots and horizontal bars represent the median values. Females are denoted by [∇], males are denoted by [].