Figure 2: Receiver operating characteristic (ROC) curves for the ability of serum Dkk–3 levels to discriminate between healthy controls and patients with CRC (CRC). At 90% specificity, serum Dkk–3 levels distinguished CRC patients (all Dukes´ stages) with 36% sensitivity. At 90% specificity, the sensitivity was 24%, 32%, 47% and 38%, respectively for Dukes´ stages A, B, C, and D. Diagnostic subgroups are denoted as follows: CRC (encompassing all Dukes´ stages) [], Dukes´ A [], Dukes´ B [], Dukes´ C [], Dukes´ D []. The line of identity is represented by a grey dashed line.