Representative
Figure 6: DES CSI: Representative 13C CSI from tumor bearing animals after intravenous injection of 20 μmol of hyperpolarized diethyl succinate. Tumors are labeled and circled for clarity. A. In RENCA tumor bearing animals, CSI reveals pronounced uptake in the tumor and some metabolically active areas. The image on the top is the heat map generated from the CSI in a RENCA tumor bearing animal and the highlighted voxel’s spectrum is below the image. B. In lymphoma A20 tumor bearing animals, CSI reveals little uptake and metabolism of hyperpolarized DES. The spectrum from the voxel with the majority of signal can be seen in more detail below the heat map and only one peak for DES is seen. C. The heat map generated from the CSI in a 4T1 breast tumor bearing animal reveals little tumor uptake but metabolism is seen in some of the voxels within the CSI matrix.