| Cells |
Average DES uptake in 1 hr* |
13C fumarate in media** |
13C lactate in media** |
| RENCA |
4 % (n = 3) |
1.2 ± 0.2 (+DES)
0.44 ±0.09 (-DES)
P = 0.005 |
9.2 ± 2.7 (+ DES)
4.7 ± 0.58 (-DES)
P = 0.05 |
| Breast 4T1 |
4 % (n = 3) |
|
2.9 ± 0.5 (+DES)
1.8 ±0.2 (-DES)
P = 0.02 |
| Lymphoma A20 |
0% (n = 2) |
|
|
*The DES uptake experiments for RENCA and 4T1 cell line were highly variable from 32-22% to 0% after a one hour incubation.
**Normalized concentration of fumarate and lactate in lyophilized media after 8 hour incubation with DES (+) or without DES (-). In addition, the difference between 13C lactate (DES +) values between RENCA and 4T1 is significant (P < 0.02). |
