Risk of Progressive Disease (%)  
Mitotic Index Size, cm Gastric Duodenum Jejunum and Ileum Rectum
<5/50-HPFs <2cm None  None None None
<5/50-HPFs >2 to <5 cm Very Low(1.9) Low (8.3) Low (4.3) Low (8.5)
<5/50-HPFs >5 to <10 cm Low (3.6) Insufficient data Moderate (24) Insufficient data
<5/50-HPFs >10 cm Moderate (12)  High (34) High (52) High (57)
<5/50-HPFs <2 cm None† Insufficient data High† High (54)
<5/50-HPFs >2 to <5 cm Moderate (16) High (50) High (73) High (52)
<5/50-HPFs >5 to 10 cm High (55) Insufficient data High (85) Insufficient data
<5/50-HPFs >10 cm High (86) High (86) High (90) High (71)
*Adapted from Miettinen M, Lasota RJ. Gastrointestinal stromal tumours: pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23:70–8326.
Abbreviations: GIST: Gastrointestinal Stromal Tumor ; HPF: high-power field.
Table 1: Risk stratification of primary GISTs based on mitotic index, tumour size, and anatomic site.*