Figure 2: Effects of resveratrol on hepatic CD31 expression during DENA-initiated hepatocarcinogenesis in female Sprague-Dawley rats. Rats were sacrificed 20 weeks following the commencement of the study and immunohistochemistry was performed to detect CD31. Arrowheads indicate immunohistochemical staining of CD31 (magnification: 100). (A) Near absence of immunopositivity in normal liver; (B) and (C) intense immunoreactivity in DENA control liver; (D) no alteration of expression in 50 mg/kg resveratrol group; (E) decreased expression in 100 mg/kg resveratrol group; and (F) near absence of CD31 expression in 300 mg/kg resveratrol group are noticed.