Figure 1: Real-time fluorescent imaging of tumor-bearing mice in the conventional and superficial orthotopic implantation model of HT-29 colon cancer. A. B and C: Day 7, 14 and 21 after superficial orthotopic implantation, respectively. D. E and F: Day 7, 14 and 21 after conventional orthotopic implantation, respectively. Superficial and conventional orthotopic implantation were performed as described in the Materials and Methods.