| Tyrosine kinase |
Mechanism |
Examples |
| EGFR (ErbB1) |
Mutation (EGFR-vIII) |
Gliomas |
| |
Mutations in TK-domain |
Non-small cell lung cancer |
| |
Over-expression or growth factor mediated activation |
Head- and neck, lung-, breast-, prostate- and colorectal cancer |
| HER2 (ErbB2) |
Over-expression (e.g. amplification of the gene) |
Breast-, ovary- and lung cancer |
| c-Kit (cellular homolog of the feline sarcoma viral oncogene) |
Mutation (constitutive TK activity) |
Gastrointestinal stromal tumors (GIST) |
| PDGFR (platelet-derived growth factor receptor) |
Mutations |
Fibrosarcoma, chronic myelomocytic leukaemia |
| |
| Non-receptor tyrosine kinases |
| Bcr-Abl (Breakpoint cluster region-Abelson) |
Mutation (translocation) |
Chronic myeloid leukemia |
