Tyrosine kinase                        Mechanism   Examples
EGFR (ErbB1) Mutation (EGFR-vIII) Gliomas
  Mutations in TK-domain Non-small cell lung cancer
  Over-expression or growth factor mediated activation Head- and neck, lung-, breast-, prostate- and colorectal cancer
HER2 (ErbB2) Over-expression (e.g. amplification of the gene) Breast-, ovary- and lung cancer
c-Kit (cellular homolog of the feline sarcoma viral oncogene) Mutation (constitutive TK activity) Gastrointestinal stromal tumors (GIST)
PDGFR (platelet-derived growth factor receptor) Mutations Fibrosarcoma, chronic myelomocytic leukaemia 
Non-receptor tyrosine kinases
Bcr-Abl (Breakpoint cluster region-Abelson) Mutation (translocation) Chronic myeloid  leukemia
Table1: Examples of dysregulated tyrosine kinases in various cancer types [29-31].