LOW-FAT DIET (10% Kcal-fat) HIGH-FAT DIET (DIO; 55% Kcal-fat)
 

Untreated

PEG-LPrA2 treated

Untreated

PEG-LPrA2 treated

 

Lean-C

Lean-I

Lean-II

   DIO-C

DIO-I

DIO-II

Mammary tumors

0/6 (0%)

0/7 (0%)

0/7 (0%)

3/14 (21%)

0/7 (0%)

0/7 (0%)

Lymphoid tumors

0/6 (0%)

1/7 (14%)

2/7 (29%)

3/14 (21%)

  0/7 (0%)

4/7 (57%)

Skin tumors

4/6 (67%)

4/7 (57%)

1/7 (14%)

8/14 (57%)

 3/7 (43%)

5/7 (71%)

Table 2: Incidence of mammary and non-mammary tumors in mice challenged with DMBA, treated and untreated with PEG-LPrA2, and fed with control or DIO-diets.